The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
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چکیده
منابع مشابه
The RING finger domain of MDM2 is essential for MDM2- mediated TGF-β resistance
In this study, we attempt to gain insights into the molecular mechanism underlying MDM2-mediated TGF-β resistance. MDM2 renders cells refractory to TGF-β by overcoming a TGF-β-induced G1 cell cycle arrest. Because the TGF-β resistant phenotype is reversible upon removal of MDM2, MDM2 likely confers TGF-β resistance by directly targeting the cellular machinery involved in the growth inhibition b...
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Resistance to chemotherapy targeting microtubules could be partially because of the delay in chromosome condensation and segregation during mitosis. The Chfr pathway has been defined recently, and its activation causes a delay in chromosome condensation in response to mitotic stress. Because Chfr contains a RING-finger domain, we tested whether Chfr inhibits chromosome condensation through an u...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 1996
ISSN: 1076-1551,1528-3658
DOI: 10.1007/bf03401903